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Found 1 hit Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily KQT member 2' and Ligand = 'BDBM50463348'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily KQT member 2


(Homo sapiens (Human))		BDBM50463348
PNG
(CHEMBL4246239)
Show SMILES Cc1cc(cc(C)c1NC(=O)CC(C)(C)C)N1CCc2sc(cc2C1)C#N
Show InChI InChI=1S/C22H27N3OS/c1-14-8-17(9-15(2)21(14)24-20(26)11-22(3,4)5)25-7-6-19-16(13-25)10-18(12-23)27-19/h8-10H,6-7,11,13H2,1-5H3,(H,24,26)
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n/an/an/an/a 290n/an/an/an/a



Nanjing University of Technology

Curated by ChEMBL


Assay Description
Channel opening activity at KCNQ2 (unknown origin) expressed in CHO cells after 10 mins by atomic absorption spectrophotometry-based Rb+ flow assay

Bioorg Med Chem Lett 28: 3004-3008 (2018)


Article DOI: 10.1016/j.bmcl.2018.05.019
BindingDB Entry DOI: 10.7270/Q2H997WB
More data for this
Ligand-Target Pair