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Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50476932'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50476932
PNG
(CHEMBL391173)
Show SMILES CCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H24ClNO3S/c1-4-5-15(3)21(19-12-17(20)9-8-16(19)13-22)25(23,24)18-10-6-14(2)7-11-18/h6-12,15,22H,4-5,13H2,1-3H3/t15-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Research and Development

Curated by ChEMBL


Assay Description
Inhibition of gamma secretase-mediated beta-APP cleavage in human H4 cells assessed by measuring Abeta40 production by ELISA

Bioorg Med Chem Lett 17: 4432-6 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.022
BindingDB Entry DOI: 10.7270/Q2708465
More data for this
Ligand-Target Pair