Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Presenilin-1 (Homo sapiens (Human)) | BDBM50477143![]() (CHEMBL392113) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of human gamma secretase assessed as amyloid-beta40 peptide production in HEK293 cells by ELISA | Bioorg Med Chem Lett 17: 5918-23 (2007) Article DOI: 10.1016/j.bmcl.2007.07.078 BindingDB Entry DOI: 10.7270/Q28S4SNK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50477143![]() (CHEMBL392113) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0750 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd Curated by ChEMBL | Assay Description Inhibition of human gamma secretase in HEK293 cells by reporter gene assay | Bioorg Med Chem Lett 17: 5918-23 (2007) Article DOI: 10.1016/j.bmcl.2007.07.078 BindingDB Entry DOI: 10.7270/Q28S4SNK | |||||||||||
More data for this Ligand-Target Pair |