Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50477510'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50477510 (CHEMBL246370) Show SMILES C[C@H](NC(=O)Cc1ccc(F)cc1)C(=O)NC1c2ccccc2C=NN(C)C1=O |c:25| Show InChI InChI=1S/C21H21FN4O3/c1-13(24-18(27)11-14-7-9-16(22)10-8-14)20(28)25-19-17-6-4-3-5-15(17)12-23-26(2)21(19)29/h3-10,12-13,19H,11H2,1-2H3,(H,24,27)(H,25,28)/t13-,19?/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cells				Bioorg Med Chem Lett 17: 4006-11 (2007) Article DOI: 10.1016/j.bmcl.2007.04.082 BindingDB Entry DOI: 10.7270/Q2XD14GF
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