Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50477529'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50477529 (CHEMBL397843) Show SMILES CC(C)C[C@H](NC(=O)[C@H](O)c1ccccc1)C(=O)NC1c2ccccc2C=NN(C)C1=O |c:28| Show InChI InChI=1S/C24H28N4O4/c1-15(2)13-19(26-23(31)21(29)16-9-5-4-6-10-16)22(30)27-20-18-12-8-7-11-17(18)14-25-28(3)24(20)32/h4-12,14-15,19-21,29H,13H2,1-3H3,(H,26,31)(H,27,30)/t19-,20?,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of gamma secretase assessed as reduction of amyloid beta level in H4 cells				Bioorg Med Chem Lett 17: 4006-11 (2007) Article DOI: 10.1016/j.bmcl.2007.04.082 BindingDB Entry DOI: 10.7270/Q2XD14GF
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