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Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50477914'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Presenilin-1


(Homo sapiens (Human))		BDBM50477914
PNG
(CHEMBL252694)
Show SMILES CC(C)C(=O)NCCC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H28Cl2N2O4S/c1-15(2)22(28)25-12-4-5-16(3)26(21-13-19(24)7-6-17(21)14-27)31(29,30)20-10-8-18(23)9-11-20/h6-11,13,15-16,27H,4-5,12,14H2,1-3H3,(H,25,28)/t16-/m1/s1
PDB
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 14n/an/an/an/an/an/a



Bristol-Myers Squibb

Curated by ChEMBL


Assay Description
Inhibition of human gamma secretase in H4 cells assessed as reduction of amyloid beta-40 levels

Bioorg Med Chem Lett 18: 175-8 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.105
BindingDB Entry DOI: 10.7270/Q2K0772B
More data for this
Ligand-Target Pair