Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50483253'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50483253 (CHEMBL1641621) Show SMILES COc1cc(ccc1-n1cnc(C)c1)-c1nnc2N(Cc3ccc(F)cc3)CCCn12 Show InChI InChI=1S/C23H23FN6O/c1-16-13-29(15-25-16)20-9-6-18(12-21(20)31-2)22-26-27-23-28(10-3-11-30(22)23)14-17-4-7-19(24)8-5-17/h4-9,12-13,15H,3,10-11,14H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	649	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of gamma secretase-mediated amyloid beta42 production in HEK293 cells by sandwich immunoassay				Bioorg Med Chem Lett 21: 664-9 (2011) Article DOI: 10.1016/j.bmcl.2010.12.012 BindingDB Entry DOI: 10.7270/Q2930X12
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