Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50483743'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Presenilin-1 (Homo sapiens (Human))	BDBM50483743 (CHEMBL1770899) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(cn1)C(C)(C)CNCC1CCOCC1 |r| Show InChI InChI=1S/C26H37F2N5O3/c1-4-5-22(31-24(34)12-19-10-20(27)13-21(28)11-19)25(35)32-23-15-33(17-30-23)26(2,3)16-29-14-18-6-8-36-9-7-18/h10-11,13,15,17-18,22,29H,4-9,12,14,16H2,1-3H3,(H,31,34)(H,32,35)/t22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 40) production by whole ce...				Bioorg Med Chem Lett 21: 2631-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.117 BindingDB Entry DOI: 10.7270/Q2K64MX1
					More data for this Ligand-Target Pair
Presenilin-1 (Homo sapiens (Human))	BDBM50483743 (CHEMBL1770899) Show SMILES CCC[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)Nc1cn(cn1)C(C)(C)CNCC1CCOCC1 |r| Show InChI InChI=1S/C26H37F2N5O3/c1-4-5-22(31-24(34)12-19-10-20(27)13-21(28)11-19)25(35)32-23-15-33(17-30-23)26(2,3)16-29-14-18-6-8-36-9-7-18/h10-11,13,15,17-18,22,29H,4-9,12,14,16H2,1-3H3,(H,31,34)(H,32,35)/t22-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of gamma-secretase in human HeLa cells assessed as inhibition of amyloid beta (1 to 40) production by DELFIA-based immunoassay				Bioorg Med Chem Lett 21: 2631-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.117 BindingDB Entry DOI: 10.7270/Q2K64MX1
					More data for this Ligand-Target Pair