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Found 1 hit Enz. Inhib. hit(s) with Target = 'Progesterone receptor' and Ligand = 'BDBM50198674'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))		BDBM50198674
PNG
(CHEMBL3965979)
Show SMILES Fc1c(F)c(F)c(Cn2c(ccc2-c2ccc3oc(=O)ccc3c2)C#N)c(F)c1F
Show InChI InChI=1S/C21H9F5N2O2/c22-17-13(18(23)20(25)21(26)19(17)24)9-28-12(8-27)3-4-14(28)10-1-5-15-11(7-10)2-6-16(29)30-15/h1-7H,9H2
PDB

KEGG

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PC cid
PC sid
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Similars
Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Ochanomizu University

Curated by ChEMBL


Assay Description
Antagonist activity at PR in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase expression after 24 hrs by alkaline...

Bioorg Med Chem 24: 5602-5610 (2016)


Article DOI: 10.1016/j.bmc.2016.09.020
BindingDB Entry DOI: 10.7270/Q2R49SRM
More data for this
Ligand-Target Pair