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Found 1 hit Enz. Inhib. hit(s) with Target = 'Proline-rich AKT1 substrate 1' and Ligand = 'BDBM386014'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proline-rich AKT1 substrate 1


(Homo sapiens (Human))		BDBM386014
PNG
(2-(4-fluorophenyl)-2-[4-(7,8-dihydro-6H-pyrimido[5...)
Show SMILES NCC(N1CCN(CC1)c1ncnc2NCCOc12)c1ccc(F)cc1
Show InChI InChI=1S/C18H23FN6O/c19-14-3-1-13(2-4-14)15(11-20)24-6-8-25(9-7-24)18-16-17(22-12-23-18)21-5-10-26-16/h1-4,12,15H,5-11,20H2,(H,21,22,23)
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US Patent
n/an/a 62n/an/an/an/an/an/a



University of Wisconsin at Madison



Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...

J Med Chem 51: 7243-52 (2008)


BindingDB Entry DOI: 10.7270/Q26M394B
More data for this
Ligand-Target Pair