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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proline-rich AKT1 substrate 1' and Ligand = 'BDBM386015'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proline-rich AKT1 substrate 1


(Homo sapiens (Human))		BDBM386015
PNG
(US10287300, Compound A21 | [2-[4-(6,7-Dihydro-5H-p...)
Show SMILES CN(C)CC(N1CCN(CC1)c1ncnc2NCCc12)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1S/C21H26F4N6/c1-29(2)12-18(14-3-4-16(17(22)11-14)21(23,24)25)30-7-9-31(10-8-30)20-15-5-6-26-19(15)27-13-28-20/h3-4,11,13,18H,5-10,12H2,1-2H3,(H,26,27,28)
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n/an/a 750n/an/an/an/an/an/a



University of Wisconsin at Madison



Assay Description
A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose response cu...

J Med Chem 51: 7243-52 (2008)


BindingDB Entry DOI: 10.7270/Q26M394B
More data for this
Ligand-Target Pair