Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description This assay is described in Bachovchin et al. Nature Chemical Biology 10, 656-663 (2014). Briefly, purified enzymes are coupled to Luminex microsphere... | Citation and Details BindingDB Entry DOI: 10.7270/Q28W3J7Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details BindingDB Entry DOI: 10.7270/Q26D5Z4W | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 73 | n/a | n/a | n/a | n/a | n/a | n/a |
Tufts University Sackler School of Biomedical Sciences Curated by ChEMBL | Assay Description Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mins prior to substrate addition by fluorescence assay | J Med Chem 56: 3467-77 (2013) Article DOI: 10.1021/jm400351a BindingDB Entry DOI: 10.7270/Q2C53N7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UA) Curated by ChEMBL | Assay Description Inhibition of human recombinant PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate incubated for 15 mins prior to substra... | ACS Med Chem Lett 4: 491-6 (2013) Article DOI: 10.1021/ml300410d BindingDB Entry DOI: 10.7270/Q2KP83J7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of recombinant human PREP purified from Escherichia coli using Z-Gly-Pro-p-nitroanilide as substrate by spectrophotometry | J Med Chem 57: 3053-74 (2014) Article DOI: 10.1021/jm500031w BindingDB Entry DOI: 10.7270/Q2P84DFW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp (UA) Curated by ChEMBL | Assay Description Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme fo... | Bioorg Med Chem Lett 22: 3412-7 (2012) Article DOI: 10.1016/j.bmcl.2012.03.107 BindingDB Entry DOI: 10.7270/Q27D2W5P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University Curated by ChEMBL | Assay Description Inhibition of POP (unknown origin) | J Med Chem 62: 7874-7884 (2019) Article DOI: 10.1021/acs.jmedchem.9b00642 BindingDB Entry DOI: 10.7270/Q2FB5682 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of PREP (unknown origin) using AMC substrate by fluorometric assay | Citation and Details Article DOI: 10.1016/j.bmcl.2021.127846 BindingDB Entry DOI: 10.7270/Q2PN999J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Tufts University School of Medicine Curated by ChEMBL | Assay Description Inhibition of prolyl oligopeptidase | Bioorg Med Chem Lett 17: 507-10 (2007) Article DOI: 10.1016/j.bmcl.2006.10.012 BindingDB Entry DOI: 10.7270/Q2T43SQH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolyl endopeptidase (Homo sapiens (Human)) | BDBM50050513![]() ((R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. Curated by ChEMBL | Assay Description Compound was tested in vitro for inhibition of Prolyl endopeptidase | J Med Chem 39: 2087-94 (1996) Article DOI: 10.1021/jm950732f BindingDB Entry DOI: 10.7270/Q29Z95K5 | |||||||||||
More data for this Ligand-Target Pair |