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Found 1 hit Enz. Inhib. hit(s) with Target = 'Prolyl hydroxylase EGLN2' and Ligand = 'BDBM385719'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prolyl hydroxylase EGLN2


(Homo sapiens (Human))		BDBM385719
PNG
(US10287286, Example 124 | tert-butyl N-[5-(4- cyan...)
Show SMILES CC(C)(C)OC(=O)Nc1cc(-c2ccc(C#N)c(F)c2)n2ncnc2c1
Show InChI InChI=1S/C18H16FN5O2/c1-18(2,3)26-17(25)23-13-7-15(24-16(8-13)21-10-22-24)11-4-5-12(9-20)14(19)6-11/h4-8,10H,1-3H3,(H,23,25)
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n/an/a 49n/an/an/an/an/an/a



Universita degli Studi di Firenze



Assay Description
The IC50 values for the PHD1 enzyme (residues 1-407) were determined by mixing increasing amounts of a compound of the invention with a fixed amount ...

Bioorg Med Chem 16: 7424-8 (2008)


BindingDB Entry DOI: 10.7270/Q2QJ7KMD
More data for this
Ligand-Target Pair