Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM261783'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM261783 (1-(Cyclopropylmethyl)-2-(9-methyl-9H-carbazol-3-yl...) Show SMILES Cn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O Show InChI InChI=1S/C25H21N3O2/c1-27-21-5-3-2-4-18(21)19-12-16(8-10-22(19)27)24-26-20-13-17(25(29)30)9-11-23(20)28(24)14-15-6-7-15/h2-5,8-13,15H,6-7,14H2,1H3,(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay				J Med Chem 62: 2541-2563 (2019) Article DOI: 10.1021/acs.jmedchem.8b01862 BindingDB Entry DOI: 10.7270/Q25H7KSB
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM261783 (1-(Cyclopropylmethyl)-2-(9-methyl-9H-carbazol-3-yl...) Show SMILES Cn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(O)=O Show InChI InChI=1S/C25H21N3O2/c1-27-21-5-3-2-4-18(21)19-12-16(8-10-22(19)27)24-26-20-13-17(25(29)30)9-11-23(20)28(24)14-15-6-7-15/h2-5,8-13,15H,6-7,14H2,1H3,(H,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	39.4	n/a	n/a	n/a	n/a	n/a	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description 4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...				US Patent US9708311 (2017) BindingDB Entry DOI: 10.7270/Q23F4RPM
					More data for this Ligand-Target Pair