Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM261844'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM261844 (2-(9-Ethyl-9H-carbazol-3-y1)-1-methyl-1 H-benzimid...) Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C)C(O)=O Show InChI InChI=1S/C23H19N3O2/c1-3-26-19-7-5-4-6-16(19)17-12-14(8-10-20(17)26)22-24-18-13-15(23(27)28)9-11-21(18)25(22)2/h4-13H,3H2,1-2H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	166	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay				J Med Chem 62: 2541-2563 (2019) Article DOI: 10.1021/acs.jmedchem.8b01862 BindingDB Entry DOI: 10.7270/Q25H7KSB
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM261844 (2-(9-Ethyl-9H-carbazol-3-y1)-1-methyl-1 H-benzimid...) Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1C)C(O)=O Show InChI InChI=1S/C23H19N3O2/c1-3-26-19-7-5-4-6-16(19)17-12-14(8-10-20(17)26)22-24-18-13-15(23(27)28)9-11-21(18)25(22)2/h4-13H,3H2,1-2H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	195	n/a	n/a	n/a	n/a	n/a	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description 4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...				US Patent US9708311 (2017) BindingDB Entry DOI: 10.7270/Q23F4RPM
					More data for this Ligand-Target Pair