BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM261894'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM261894 (2-(8-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.19	n/a	n/a	n/a	n/a	n/a	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description 4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...				US Patent US9708311 (2017) BindingDB Entry DOI: 10.7270/Q23F4RPM
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM261894 (2-(8-Chloro-9-ethyl-9H-carbazol-3-yl)-1-(2-methoxy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay				J Med Chem 62: 2541-2563 (2019) Article DOI: 10.1021/acs.jmedchem.8b01862 BindingDB Entry DOI: 10.7270/Q25H7KSB
Bayer AG Curated by ChEMBL					More data for this Ligand-Target Pair