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Found 1 hit Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM50163378'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor EP4 subtype


(Homo sapiens (Human))		BDBM50163378
PNG
(CHEMBL3793912)
Show SMILES COC1CCN(CC1)c1ccc(C)c(n1)C(=O)Nc1c(C)cc(cc1C)C(O)=O
Show InChI InChI=1S/C22H27N3O4/c1-13-5-6-18(25-9-7-17(29-4)8-10-25)23-20(13)21(26)24-19-14(2)11-16(22(27)28)12-15(19)3/h5-6,11-12,17H,7-10H2,1-4H3,(H,24,26)(H,27,28)
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n/an/a 97n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity against human EP4 expressed in HEK293 cells assessed as inhibition of PGE2-stimulated production of cAMP incubated for 20 mins by...

Bioorg Med Chem Lett 26: 2303-7 (2016)


Article DOI: 10.1016/j.bmcl.2016.03.041
BindingDB Entry DOI: 10.7270/Q22F7QBJ
More data for this
Ligand-Target Pair