Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Prostaglandin E2 receptor EP4 subtype' and Ligand = 'BDBM50499954'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50499954 (CHEMBL3741902) Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(nc2ccccc12)-c1cccc(CO)c1 Show InChI InChI=1S/C26H22N2O4/c1-15-10-11-19(26(31)32)16(2)24(15)28-25(30)21-13-23(18-7-5-6-17(12-18)14-29)27-22-9-4-3-8-20(21)22/h3-13,29H,14H2,1-2H3,(H,28,30)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor				Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50499954 (CHEMBL3741902) Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(nc2ccccc12)-c1cccc(CO)c1 Show InChI InChI=1S/C26H22N2O4/c1-15-10-11-19(26(31)32)16(2)24(15)28-25(30)21-13-23(18-7-5-6-17(12-18)14-29)27-22-9-4-3-8-20(21)22/h3-13,29H,14H2,1-2H3,(H,28,30)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation				Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50499954 (CHEMBL3741902) Show SMILES Cc1ccc(C(O)=O)c(C)c1NC(=O)c1cc(nc2ccccc12)-c1cccc(CO)c1 Show InChI InChI=1S/C26H22N2O4/c1-15-10-11-19(26(31)32)16(2)24(15)28-25(30)21-13-23(18-7-5-6-17(12-18)14-29)27-22-9-4-3-8-20(21)22/h3-13,29H,14H2,1-2H3,(H,28,30)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	312	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Antagonist activity at EP4 receptor in human whole blood assessed as reversal of inhibition of PGE2 mediated LPS-induced TNF alpha production pretrea...				Bioorg Med Chem Lett 26: 105-9 (2016) Article DOI: 10.1016/j.bmcl.2015.11.023 BindingDB Entry DOI: 10.7270/Q2G73HRK
					More data for this Ligand-Target Pair