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Found 1 hit Enz. Inhib. hit(s) with Target = 'Prostaglandin G/H synthase 2' and Ligand = 'BDBM50365160'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin G/H synthase 2


(Homo sapiens (Human))		BDBM50365160
PNG
(CHEMBL1950012)
Show SMILES Cc1ccnc(c1)C(=O)c1[nH]c2ccc(cc2c1CC(O)=O)C(C)(C)C
Show InChI InChI=1S/C21H22N2O3/c1-12-7-8-22-17(9-12)20(26)19-15(11-18(24)25)14-10-13(21(2,3)4)5-6-16(14)23-19/h5-10,23H,11H2,1-4H3,(H,24,25)
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n/an/a 42n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of COX-2-mediated 6-keto-PGF1alpha production in IL-1beta-induced HUVEC preincubated for 20 mins prior A23187 stimulation measured after 1...

Eur J Med Chem 50: 179-95 (2012)


Article DOI: 10.1016/j.ejmech.2012.01.053
BindingDB Entry DOI: 10.7270/Q2B27VR8
More data for this
Ligand-Target Pair