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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein Wnt-3a' and Ligand = 'BDBM374994'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Wnt-3a


(Homo sapiens (Human))		BDBM374994
PNG
(N-(5-(4-acetylpiperazin-1-yl)pyridin-2-yl)-2-(2'-m...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NC(=O)Cc2cnc(-c3ccnc(C)c3)c(c2)C(F)(F)F)nc1
Show InChI InChI=1S/C25H25F3N6O2/c1-16-11-19(5-6-29-16)24-21(25(26,27)28)12-18(14-31-24)13-23(36)32-22-4-3-20(15-30-22)34-9-7-33(8-10-34)17(2)35/h3-6,11-12,14-15H,7-10,13H2,1-2H3,(H,30,32,36)
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US Patent
n/an/a 0.100n/an/an/an/an/an/a



St. Jude Research Hospital



Assay Description
Human embryonic kidney 293 cells (obtained from American Type Culture Collection, ATCC, Manassas, Va.) are cultured in DMEM medium (Gibco/Invitrogen,...

J Med Chem 50: 5727-34 (2007)


BindingDB Entry DOI: 10.7270/Q2GM89KJ
More data for this
Ligand-Target Pair