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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14000'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))
BDBM14000
PNG
((6R)-23-chloro-27-oxo-20-oxa-3,7,11,13-tetraazapen...)
Show SMILES Clc1cc2CN3CC[C@@H](NCc4cncn4Cc4ccc(C#N)c(Oc(c1)c2)c4)C3=O |r|
Show InChI InChI=1S/C23H20ClN5O2/c24-18-5-16-6-20(8-18)31-22-7-15(1-2-17(22)9-25)12-29-14-26-10-19(29)11-27-21-3-4-28(13-16)23(21)30/h1-2,5-8,10,14,21,27H,3-4,11-13H2/t21-/m1/s1
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MMDB

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Similars

Article
PubMed
n/an/a 23n/an/an/an/a7.530



Merck Research Laboratories



Assay Description
Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...


J Med Chem 45: 2388-409 (2002)


Article DOI: 10.1021/jm010531d
BindingDB Entry DOI: 10.7270/Q2T72FPK
More data for this
Ligand-Target Pair