Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14022'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM14022 ((1R,2R,5R)-6-methyl-29-oxo-19-oxa-2,6,10,12-tetraa...) Show SMILES CN1Cc2cncn2Cc2ccc(C#N)c(Oc3ccc4CC[C@@H](N5CC[C@@H]1C5=O)c4c3)c2 |r| Show InChI InChI=1S/C26H25N5O2/c1-29-15-20-13-28-16-30(20)14-17-2-3-19(12-27)25(10-17)33-21-6-4-18-5-7-23(22(18)11-21)31-9-8-24(29)26(31)32/h2-4,6,10-11,13,16,23-24H,5,7-9,14-15H2,1H3/t23-,24-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories					Assay Description Compounds were tested as inhibitors of FTase in vitro using purified recombinant human enzyme to catalyze the reaction between [3H]FPP and a recombin...				J Med Chem 45: 2388-409 (2002) Article DOI: 10.1021/jm010531d BindingDB Entry DOI: 10.7270/Q2T72FPK
					More data for this Ligand-Target Pair				3D Structure (docked)