Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50071700'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50071700 (CHEMBL81889 | Cyanoguanidine derivative) Show SMILES Clc1ccc2c(-[#16]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](-[#7]-[#6]-c2ccncc2)=[#7]C#N)c1 |w:30.34| Show InChI InChI=1S/C26H23ClN6S/c27-21-3-4-22-23(14-21)34-16-20-2-1-9-30-25(20)24(22)19-7-12-33(13-8-19)26(32-17-28)31-15-18-5-10-29-11-6-18/h1-6,9-11,14H,7-8,12-13,15-16H2,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro FPT potency by measuring the ability to inhibit the transfer of [3H]-farnesyl from farnesyl pyrophosphate to H-Ras-CLVS.				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50071700 (CHEMBL81889 | Cyanoguanidine derivative) Show SMILES Clc1ccc2c(-[#16]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](-[#7]-[#6]-c2ccncc2)=[#7]C#N)c1 |w:30.34| Show InChI InChI=1S/C26H23ClN6S/c27-21-3-4-22-23(14-21)34-16-20-2-1-9-30-25(20)24(22)19-7-12-33(13-8-19)26(32-17-28)31-15-18-5-10-29-11-6-18/h1-6,9-11,14H,7-8,12-13,15-16H2,(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of Ras processing in COS cells				Bioorg Med Chem Lett 8: 2521-6 (1999) BindingDB Entry DOI: 10.7270/Q24M93PP
					More data for this Ligand-Target Pair