Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50133903'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50133903 (CHEMBL452318) Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1 Show InChI InChI=1S/C26H29N7O2S/c1-30-19-26(29-21-30)36(34,35)33(17-23-7-4-3-5-8-23)14-6-13-32(18-25-16-28-20-31(25)2)24-11-9-22(15-27)10-12-24/h3-5,7-12,16,19-21H,6,13-14,17-18H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLS				J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC
					More data for this Ligand-Target Pair