Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50134040'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50134040 (CHEMBL1256440) Show SMILES Cn1cnc(c1)S(=O)(=O)N(CCN(Cc1cncn1C)c1c(F)cc(cc1F)C#N)CC1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C28H32F2N10O2S/c1-36-18-26(35-20-36)43(41,42)40(16-21-4-8-38(9-5-21)28-33-6-3-7-34-28)11-10-39(17-23-15-32-19-37(23)2)27-24(29)12-22(14-31)13-25(27)30/h3,6-7,12-13,15,18-21H,4-5,8-11,16-17H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLS				J Med Chem 53: 6867-88 (2010) Article DOI: 10.1021/jm1001748 BindingDB Entry DOI: 10.7270/Q26110JC
					More data for this Ligand-Target Pair