Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50139466'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM50139466 (CHEMBL3765154) Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1sc(NCc2cncn2Cc2ccc(cc2)C#N)c(C#N)c1-c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C30H27ClN6O3S2/c1-40-30(39)25(11-12-41-2)36-28(38)27-26(21-7-9-22(31)10-8-21)24(14-33)29(42-27)35-16-23-15-34-18-37(23)17-20-5-3-19(13-32)4-6-20/h3-10,15,18,25,35H,11-12,16-17H2,1-2H3,(H,36,38)/t25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
CNRS UPR2301 Curated by ChEMBL					Assay Description Inhibition of human recombinant farnesyltransferase using farnesyl pyrophosphate and Dansyl-GCVLS peptide after 15 mins by fluorescence assay				Eur J Med Chem 109: 173-86 (2016) Article DOI: 10.1016/j.ejmech.2015.12.045 BindingDB Entry DOI: 10.7270/Q25B04C6
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