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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50283066'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50283066
PNG
((4E,8E)-2-({1-[1-((S)-1-(S)-Carboxy-2-hydroxy-ethy...)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6]-[#6](-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](-[#8])=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](-[#8])=O
Show InChI InChI=1S/C33H55N3O8/c1-20(2)11-9-12-23(7)13-10-14-24(8)15-16-25(32(41)42)18-28(38)36-29(22(5)6)31(40)34-26(17-21(3)4)30(39)35-27(19-37)33(43)44/h11,13,15,21-22,25-27,29,37H,9-10,12,14,16-19H2,1-8H3,(H,34,40)(H,35,39)(H,36,38)(H,41,42)(H,43,44)/b23-13+,24-15+/t25?,26-,27-,29-/m0/s1
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Similars
Article
n/an/a 4.50E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of ras Farnesyltransferase

Bioorg Med Chem Lett 4: 2107-2112 (1994)


Article DOI: 10.1016/S0960-894X(01)80111-6
BindingDB Entry DOI: 10.7270/Q2ZW1KTF
More data for this
Ligand-Target Pair