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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50283069'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50283069
PNG
((S)-3-Hydroxy-2-((S)-4-methyl-2-{(S)-3-methyl-2-[(...)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6]-[#6]-[#6](-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])-[#6](=O)-[#7]-[#6]P([#8])([#8])=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](-[#8])=O
Show InChI InChI=1S/C35H61N4O10P/c1-22(2)11-9-12-25(7)13-10-14-26(8)15-16-27(32(42)36-21-50(47,48)49)17-18-30(41)39-31(24(5)6)34(44)37-28(19-23(3)4)33(43)38-29(20-40)35(45)46/h11,13,15,23-24,27-29,31,40H,9-10,12,14,16-21H2,1-8H3,(H,36,42)(H,37,44)(H,38,43)(H,39,41)(H,45,46)(H2,47,48,49)/b25-13+,26-15+/t27?,28-,29-,31-/m0/s1
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n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of ras Farnesyltransferase

Bioorg Med Chem Lett 4: 2107-2112 (1994)


Article DOI: 10.1016/S0960-894X(01)80111-6
BindingDB Entry DOI: 10.7270/Q2ZW1KTF
More data for this
Ligand-Target Pair