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Found 1 hit Enz. Inhib. hit(s) with Target = 'Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50450084'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50450084
PNG
(CHEMBL2115115)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6]-[#6]-[#6@@H](-[#7]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](/[#6])-[#6])-[#6](-[#8])=O)-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](-[#8])=O
Show InChI InChI=1S/C34H58N4O8/c1-21(2)11-9-12-24(7)13-10-14-25(8)17-18-35-26(33(43)44)15-16-29(40)38-30(23(5)6)32(42)36-27(19-22(3)4)31(41)37-28(20-39)34(45)46/h11,13,17,22-23,26-28,30,35,39H,9-10,12,14-16,18-20H2,1-8H3,(H,36,42)(H,37,41)(H,38,40)(H,43,44)(H,45,46)/b24-13+,25-17+/t26-,27+,28+,30+/m1/s1
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Similars
Article
n/an/a 1.40E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of ras Farnesyltransferase

Bioorg Med Chem Lett 4: 2107-2112 (1994)


Article DOI: 10.1016/S0960-894X(01)80111-6
BindingDB Entry DOI: 10.7270/Q2ZW1KTF
More data for this
Ligand-Target Pair