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Found 1 hit Enz. Inhib. hit(s) with Target = 'Prothrombin' and Ligand = 'BDBM12949'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prothrombin


(Homo sapiens (Human))		BDBM12949
PNG
(alpha-ketothiazole analogue 9 | ethyl 2-({[(1S)-1-...)
Show SMILES [#6]-[#6]-[#8]-[#6](=O)-[#6](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-c1nccs1 |r|
Show InChI InChI=1S/C35H46N8O6S/c1-4-49-33(47)27(21-24-14-9-6-10-15-24)42-35(48)41-26(20-23-12-7-5-8-13-23)30(45)43-28(22(2)3)31(46)40-25(16-11-17-39-34(36)37)29(44)32-38-18-19-50-32/h5-10,12-15,18-19,22,25-28H,4,11,16-17,20-21H2,1-3H3,(H,40,46)(H,43,45)(H4,36,37,39)(H2,41,42,48)/t25-,26-,27?,28-/m0/s1
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Article
PubMed
n/an/a 2.10E+3n/an/an/an/an/an/a



Daiichi Asubio Medical Research Laboratories LLC (DAIAMED)



Assay Description
Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis...

J Med Chem 49: 7781-91 (2006)


Article DOI: 10.1021/jm060978s
BindingDB Entry DOI: 10.7270/Q2SJ1HTM
More data for this
Ligand-Target Pair