Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase ROS' and Ligand = 'BDBM267438'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human))	BDBM267438 (US10688100, Compound 22 | US10966985, Compound 22 ...) Show SMILES CC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C21H22FN5O2/c1-14(28)25-9-10-29-19-5-4-16(22)11-17(19)18-3-2-7-26(18)20-6-8-27-21(24-20)15(13-25)12-23-27/h4-6,8,11-12,18H,2-3,7,9-10,13H2,1H3/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	331	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10966985 (2021) BindingDB Entry DOI: 10.7270/Q2639ST6
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human))	BDBM267438 (US10688100, Compound 22 | US10966985, Compound 22 ...) Show SMILES CC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C21H22FN5O2/c1-14(28)25-9-10-29-19-5-4-16(22)11-17(19)18-3-2-7-26(18)20-6-8-27-21(24-20)15(13-25)12-23-27/h4-6,8,11-12,18H,2-3,7,9-10,13H2,1H3/t18-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	331	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description The potency of a compound inhibiting wild type and exemplary mutant ROS1 kinases was determined using CisBio's HTRF Kinease-TK assay technology. ...				US Patent US10688100 (2020) BindingDB Entry DOI: 10.7270/Q2KH0RC3
					More data for this Ligand-Target Pair