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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase Src' and Ligand = 'BDBM148343'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM148343
PNG
(US8962637, 69 | US8962637, 77)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1N1CCc2nc(Nc3ccc(cc3)C(=O)NCCCN3CCCC3)ncc2C1=O
Show InChI InChI=1S/C36H36F3N7O3/c1-23-8-11-28(42-33(48)25-6-4-7-26(20-25)36(37,38)39)21-31(23)46-19-14-30-29(34(46)49)22-41-35(44-30)43-27-12-9-24(10-13-27)32(47)40-15-5-18-45-16-2-3-17-45/h4,6-13,20-22H,2-3,5,14-19H2,1H3,(H,40,47)(H,42,48)(H,41,43,44)
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Similars
US Patent
n/an/a 17n/an/an/an/an/an/a



Debiopharm S.A.; Aurigene Discovery Technologies Ltd.

US Patent


Assay Description
Compounds were screened in the TR-FRET assay for JAK2 and c-Src kinase inhibition. Ultra light poly GT (Perkin Elmer) was used as the substrate for J...

US Patent US8962637 (2015)


BindingDB Entry DOI: 10.7270/Q2MS3RGN
More data for this
Ligand-Target Pair