Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM305683'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305683 (US10144734, Example 701 | US10172845, Example 701 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OCC2(F)CNC2)cn2ncc(C#N)c12 Show InChI InChI=1S/C30H30ClFN8O2/c1-19-4-3-5-23(31)26(19)28(41)38-29(2)6-8-39(9-7-29)25-14-35-24(13-36-25)22-10-21(42-18-30(32)16-34-17-30)15-40-27(22)20(11-33)12-37-40/h3-5,10,12-15,34H,6-9,16-18H2,1-2H3,(H,38,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Array Biopharma Inc. US Patent					Assay Description Wildtype and V804M mutant: Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's ...				US Patent US10881652 (2021) BindingDB Entry DOI: 10.7270/Q2ZG6WBN
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM305683 (US10144734, Example 701 | US10172845, Example 701 ...) Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OCC2(F)CNC2)cn2ncc(C#N)c12 Show InChI InChI=1S/C30H30ClFN8O2/c1-19-4-3-5-23(31)26(19)28(41)38-29(2)6-8-39(9-7-29)25-14-35-24(13-36-25)22-10-21(42-18-30(32)16-34-17-30)15-40-27(22)20(11-33)12-37-40/h3-5,10,12-15,34H,6-9,16-18H2,1-2H3,(H,38,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10144734 (2018) BindingDB Entry DOI: 10.7270/Q2251M8C
					More data for this Ligand-Target Pair