Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret' and Ligand = 'BDBM367708'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM367708 (US10227329, Compound 120) Show SMILES Cc1cc(Nc2cc(C)cc(n2)N2CC(C)(C2)C(=O)NCc2ccc(nc2)-n2cc(F)cn2)n[nH]1 Show InChI InChI=1S/C24H26FN9O/c1-15-6-19(29-20-8-16(2)31-32-20)30-22(7-15)33-13-24(3,14-33)23(35)27-10-17-4-5-21(26-9-17)34-12-18(25)11-28-34/h4-9,11-12H,10,13-14H2,1-3H3,(H,27,35)(H2,29,30,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description In each well of a 384-well plate, 7.5 nM-10 nM of wild type RET (ProQinase 1090-0000-1) was incubated in a total of 12.5 μL of buffer (100 mM HE...				J Med Chem 51: 1231-41 (2008) BindingDB Entry DOI: 10.7270/Q22V2JDM
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