Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]' and Ligand = 'BDBM296211'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296211 (US10112942, Example 18 | US10137124, Example 18 | ...) Show SMILES N#Cc1cnn2cc(OCC3COC3)cc(-c3ccc(nc3)N3CCN(Cc4ccccc4)CC3)c12 Show InChI InChI=1S/C28H28N6O2/c29-13-24-15-31-34-17-25(36-20-22-18-35-19-22)12-26(28(24)34)23-6-7-27(30-14-23)33-10-8-32(9-11-33)16-21-4-2-1-3-5-21/h1-7,12,14-15,17,22H,8-11,16,18-20H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE-TK assay techn...				US Patent US10555944 (2020) BindingDB Entry DOI: 10.7270/Q279473N
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114] (Homo sapiens (Human))	BDBM296211 (US10112942, Example 18 | US10137124, Example 18 | ...) Show SMILES N#Cc1cnn2cc(OCC3COC3)cc(-c3ccc(nc3)N3CCN(Cc4ccccc4)CC3)c12 Show InChI InChI=1S/C28H28N6O2/c29-13-24-15-31-34-17-25(36-20-22-18-35-19-22)12-26(28(24)34)23-6-7-27(30-14-23)33-10-8-32(9-11-33)16-21-4-2-1-3-5-21/h1-7,12,14-15,17,22H,8-11,16,18-20H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11.7	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF KinEASE -TK assay tech...				US Patent US10172851 (2019) BindingDB Entry DOI: 10.7270/Q2GM89CV
					More data for this Ligand-Target Pair