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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]' and Ligand = 'BDBM305417'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]


(Homo sapiens (Human))		BDBM305417
PNG
(3-chloro-N-(1-(5-(3- cyano-6- methoxypyrazolo[1,5-...)
Show SMILES COc1cc(-c2ccc(nc2)N2CCC(C)(CC2)NC(=O)c2ncc(F)cc2Cl)c2c(cnn2c1)C#N
Show InChI InChI=1S/C26H23ClFN7O2/c1-26(33-25(36)23-21(27)9-18(28)14-31-23)5-7-34(8-6-26)22-4-3-16(12-30-22)20-10-19(37-2)15-35-24(20)17(11-29)13-32-35/h3-4,9-10,12-15H,5-8H2,1-2H3,(H,33,36)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.20n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...

US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair