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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]' and Ligand = 'BDBM305511'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]


(Homo sapiens (Human))		BDBM305511
PNG
(US10144734, Example 528 | US10172845, Example 528 ...)
Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3ncccc3Cl)[C@H](O)C2)c2c(cnn2c1)C#N |r|
Show InChI InChI=1S/C26H24ClN7O3/c1-2-37-18-10-19(25-17(11-28)13-31-34(25)14-18)16-5-6-23(30-12-16)33-9-7-21(22(35)15-33)32-26(36)24-20(27)4-3-8-29-24/h3-6,8,10,12-14,21-22,35H,2,7,9,15H2,1H3,(H,32,36)/t21-,22+/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.40n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...

US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair