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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]' and Ligand = 'BDBM305670'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]


(Homo sapiens (Human))		BDBM305670
PNG
(US10144734, Example 688 | US10172845, Example 688 ...)
Show SMILES Cc1cccc(Cl)c1C(=O)NC1(C)CCN(CC1)c1cnc(cn1)-c1cc(OC[C@H]2CNCCO2)cn2ncc(C#N)c12 |r|
Show InChI InChI=1S/C31H33ClN8O3/c1-20-4-3-5-25(32)28(20)30(41)38-31(2)6-9-39(10-7-31)27-17-35-26(16-36-27)24-12-22(43-19-23-15-34-8-11-42-23)18-40-29(24)21(13-33)14-37-40/h3-5,12,14,16-18,23,34H,6-11,15,19H2,1-2H3,(H,38,41)/t23-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...

US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair