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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]' and Ligand = 'BDBM305713'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]


(Homo sapiens (Human))		BDBM305713
PNG
(N-((3S,4S)-3-amino-1-(5- (3-cyano-6- ethoxypyrazol...)
Show SMILES CCOc1cc(-c2ccc(nc2)N2CC[C@H](NC(=O)c3cc(F)ccc3C)[C@@H](N)C2)c2c(cnn2c1)C#N |r|
Show InChI InChI=1S/C28H28FN7O2/c1-3-38-21-11-23(27-19(12-30)14-33-36(27)15-21)18-5-7-26(32-13-18)35-9-8-25(24(31)16-35)34-28(37)22-10-20(29)6-4-17(22)2/h4-7,10-11,13-15,24-25H,3,8-9,16,31H2,1-2H3,(H,34,37)/t24-,25-/m0/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...

US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair