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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]' and Ligand = 'BDBM305793'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proto-oncogene tyrosine-protein kinase receptor Ret [658-1114]


(Homo sapiens (Human))		BDBM305793
PNG
((R)-N-(4-benzyl-1-(5-(3- cyano-6- ethoxypyrazolo[1...)
Show SMILES CCOc1cc(-c2ccc(nc2)N2CCC(Cc3ccccc3)(CC2)NC(=O)[C@H]2CCCN2C)c2c(cnn2c1)C#N |r|
Show InChI InChI=1S/C33H37N7O2/c1-3-42-27-18-28(31-26(20-34)22-36-40(31)23-27)25-11-12-30(35-21-25)39-16-13-33(14-17-39,19-24-8-5-4-6-9-24)37-32(41)29-10-7-15-38(29)2/h4-6,8-9,11-12,18,21-23,29H,3,7,10,13-17,19H2,1-2H3,(H,37,41)/t29-/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7n/an/an/an/an/an/a



Array BioPharma Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit wildtype and V804M mutant RET kinase using CisBio's HTRF® KinEASE-TK assay tech...

US Patent US10172845 (2019)


BindingDB Entry DOI: 10.7270/Q2M90BR9
More data for this
Ligand-Target Pair