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Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50347970'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347970
PNG
(CHEMBL1800390)
Show SMILES [#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6]-[#6](-[#7])=O |r|
Show InChI InChI=1S/C50H92N18O9/c1-4-13-36(63-44(73)37(15-12-25-61-50(58)59)62-42(71)31-68(26-9-6-5-7-22-51)47(76)35(54)14-11-24-60-49(56)57)43(72)65-39(28-33-17-19-34(69)20-18-33)45(74)66-40(29-53)46(75)64-38(21-16-32(2)3)48(77)67(30-41(55)70)27-10-8-23-52/h17-20,32,35-40,69H,4-16,21-31,51-54H2,1-3H3,(H2,55,70)(H,62,71)(H,63,73)(H,64,75)(H,65,72)(H,66,74)(H4,56,57,60)(H4,58,59,61)/t35-,36-,37-,38-,39-,40-/m0/s1
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 160n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair