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Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50347971'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347971
PNG
(CHEMBL1800399)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C46H80N18O10/c1-4-8-31-38(68)61-34(23-28-12-14-29(65)15-13-28)40(70)62-35(24-47)41(71)60-33(16-11-27(2)3)43(73)63(25-36(49)66)21-7-19-56-46(74)57-20-22-64(42(72)30(48)9-5-17-54-44(50)51)26-37(67)58-32(39(69)59-31)10-6-18-55-45(52)53/h12-15,27,30-35,65H,4-11,16-26,47-48H2,1-3H3,(H2,49,66)(H,58,67)(H,59,69)(H,60,71)(H,61,68)(H,62,70)(H4,50,51,54)(H4,52,53,55)(H2,56,57,74)/t30-,31-,32-,33-,34-,35-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 920n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair