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Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50347976'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347976
PNG
(CHEMBL1800567)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C51H90N18O10/c1-4-13-36-43(73)66-39(28-33-17-19-34(70)20-18-33)45(75)67-40(29-52)46(76)65-38(21-16-32(2)3)48(78)68(30-41(54)71)27-10-8-23-62-51(79)61-22-7-5-6-9-26-69(47(77)35(53)14-11-24-59-49(55)56)31-42(72)63-37(44(74)64-36)15-12-25-60-50(57)58/h17-20,32,35-40,70H,4-16,21-31,52-53H2,1-3H3,(H2,54,71)(H,63,72)(H,64,74)(H,65,76)(H,66,73)(H,67,75)(H4,55,56,59)(H4,57,58,60)(H2,61,62,79)/t35-,36-,37-,38-,39-,40-/m0/s1
PDB

UniProtKB/SwissProt

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PC cid
PC sid
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Similars

Article
PubMed
n/an/a 280n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair