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Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50347978'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50347978
PNG
(CHEMBL1800569)
Show SMILES [#6]-[#6]-[#6]-[#6@@H]-1-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6]-[#7](-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#7]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#7](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#6@H](-[#6]-[#6]-[#6](-[#6])-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-c2ccc(-[#8])cc2)-[#7]-[#6]-1=O)-[#6](=O)-[#6@@H](-[#7])-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7] |r|
Show InChI InChI=1S/C50H88N18O10/c1-4-12-35-42(72)65-38(27-32-16-18-33(69)19-17-32)44(74)66-39(28-51)45(75)64-37(20-15-31(2)3)47(77)67(29-40(53)70)25-8-6-5-7-21-60-50(78)61-24-11-26-68(46(76)34(52)13-9-22-58-48(54)55)30-41(71)62-36(43(73)63-35)14-10-23-59-49(56)57/h16-19,31,34-39,69H,4-15,20-30,51-52H2,1-3H3,(H2,53,70)(H,62,71)(H,63,73)(H,64,75)(H,65,72)(H,66,74)(H4,54,55,58)(H4,56,57,59)(H2,60,61,78)/t34-,35-,36-,37-,38-,39-/m0/s1
PDB

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PC sid
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Similars

Article
PubMed
n/an/a 320n/an/an/an/an/an/a



The Hebrew University of Jerusalem

Curated by ChEMBL


Assay Description
Inhibition of Akt using RPRTSSF peptide and [gamma32]ATP by cell-free radioactive assay


J Med Chem 54: 5154-64 (2011)


Article DOI: 10.1021/jm2003969
BindingDB Entry DOI: 10.7270/Q26D5TBX
More data for this
Ligand-Target Pair