Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50528410'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50528410 (CHEMBL4589576) Show SMILES Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CC(=O)NC2CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:28.32,(60.53,-24.37,;60.21,-25.88,;58.8,-26.5,;58.96,-28.03,;60.46,-28.36,;61.09,-29.77,;61.24,-27.03,;62.77,-26.87,;63.8,-28.01,;65.22,-27.39,;65.05,-25.86,;63.55,-25.54,;62.92,-24.13,;66.55,-28.17,;66.54,-29.7,;67.88,-27.4,;69.22,-28.17,;69.21,-29.71,;70.54,-30.48,;71.88,-29.72,;73.21,-30.49,;74.55,-29.73,;74.55,-28.19,;75.88,-30.5,;77.21,-29.74,;78.75,-29.74,;77.98,-28.4,;71.89,-28.17,;70.55,-27.4,;70.55,-25.87,;69.22,-25.1,;69.22,-23.56,;70.55,-22.79,;70.54,-21.25,;71.88,-23.55,;73.21,-22.78,;71.89,-25.1,)| Show InChI InChI=1S/C25H25Cl4N5O3/c1-34-23(19(28)10-31-34)16-9-21(37-24(16)29)25(36)33-20-11-30-14(8-22(35)32-13-3-4-13)7-15(20)12-2-5-17(26)18(27)6-12/h2,5-6,9-10,13-15,20,30H,3-4,7-8,11H2,1H3,(H,32,35)(H,33,36)/t14-,15-,20+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay				J Med Chem 62: 7264-7288 (2019) Article DOI: 10.1021/acs.jmedchem.9b00891 BindingDB Entry DOI: 10.7270/Q2XW4P7W
					More data for this Ligand-Target Pair