Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50528434'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50528434 (CHEMBL4546392) Show SMILES Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CCN2CCCC2)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:28.32,(7.84,-37.33,;7.52,-38.84,;6.11,-39.46,;6.26,-40.99,;7.77,-41.32,;8.39,-42.72,;8.54,-39.98,;10.08,-39.82,;11.11,-40.97,;12.52,-40.35,;12.36,-38.82,;10.85,-38.49,;10.23,-37.08,;13.85,-41.12,;13.85,-42.66,;15.19,-40.36,;16.52,-41.13,;16.52,-42.66,;17.85,-43.44,;19.18,-42.67,;20.51,-43.45,;21.85,-42.68,;23.18,-43.46,;23.34,-44.98,;24.85,-45.31,;25.62,-43.98,;24.59,-42.83,;19.19,-41.13,;17.86,-40.36,;17.86,-38.83,;16.52,-38.06,;16.52,-36.52,;17.85,-35.75,;17.85,-34.21,;19.19,-36.51,;20.52,-35.73,;19.19,-38.06,)| Show InChI InChI=1S/C26H29Cl4N5O2/c1-34-24(21(29)13-32-34)18-12-23(37-25(18)30)26(36)33-22-14-31-16(6-9-35-7-2-3-8-35)11-17(22)15-4-5-19(27)20(28)10-15/h4-5,10,12-13,16-17,22,31H,2-3,6-9,11,14H2,1H3,(H,33,36)/t16-,17+,22-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay				J Med Chem 62: 7264-7288 (2019) Article DOI: 10.1021/acs.jmedchem.9b00891 BindingDB Entry DOI: 10.7270/Q2XW4P7W
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