Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50528467'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50528467 (CHEMBL4519793) Show SMILES Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)N[C@@H]1CN[C@H](CCn2cncn2)C[C@H]1c1ccc(Cl)c(Cl)c1 |r,wU:16.17,19.21,wD:28.32,(35.98,-7.3,;35.66,-8.81,;34.25,-9.43,;34.4,-10.96,;35.91,-11.29,;36.53,-12.69,;36.68,-9.95,;38.22,-9.79,;39.25,-10.94,;40.66,-10.32,;40.5,-8.79,;38.99,-8.46,;38.37,-7.05,;41.99,-11.09,;41.99,-12.63,;43.33,-10.33,;44.66,-11.1,;44.66,-12.63,;45.99,-13.41,;47.32,-12.64,;48.65,-13.42,;49.99,-12.65,;51.32,-13.43,;51.48,-14.95,;52.99,-15.28,;53.76,-13.95,;52.73,-12.8,;47.33,-11.1,;46,-10.33,;46,-8.8,;44.66,-8.03,;44.66,-6.49,;45.99,-5.72,;45.99,-4.18,;47.33,-6.48,;48.66,-5.7,;47.33,-8.03,)| Show InChI InChI=1S/C24H23Cl4N7O2/c1-34-22(19(27)9-31-34)16-8-21(37-23(16)28)24(36)33-20-10-30-14(4-5-35-12-29-11-32-35)7-15(20)13-2-3-17(25)18(26)6-13/h2-3,6,8-9,11-12,14-15,20,30H,4-5,7,10H2,1H3,(H,33,36)/t14-,15+,20-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay				J Med Chem 62: 7264-7288 (2019) Article DOI: 10.1021/acs.jmedchem.9b00891 BindingDB Entry DOI: 10.7270/Q2XW4P7W
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