Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'RAC-alpha serine/threonine-protein kinase' and Ligand = 'BDBM50528478'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50528478 (CHEMBL4471578) Show SMILES O[C@H]([C@@H](O)C(O)=O)C(O)=O.Cn1ncc(Cl)c1-c1cc(oc1Cl)C(=O)NC1CNCCC1c1ccccc1 |r,wD:1.0,2.2,(7.5,-5.09,;7.5,-3.55,;6.16,-2.78,;6.16,-1.24,;4.83,-3.55,;3.49,-2.78,;4.83,-5.09,;8.83,-2.78,;10.16,-3.55,;8.83,-1.24,;-8.88,4.01,;-9.21,2.5,;-10.62,1.88,;-10.46,.35,;-8.95,.02,;-8.33,-1.38,;-8.18,1.36,;-6.65,1.51,;-5.62,.36,;-4.22,.99,;-4.37,2.52,;-5.87,2.84,;-6.5,4.25,;-2.88,.21,;-2.89,-1.33,;-1.55,.98,;-.22,.2,;-.22,-1.33,;1.11,-2.11,;2.45,-1.34,;2.45,.21,;1.12,.97,;1.13,2.51,;-.21,3.28,;-.21,4.82,;1.12,5.59,;2.46,4.83,;2.46,3.28,)| Show InChI InChI=1S/C20H20Cl2N4O2.C4H6O6/c1-26-18(15(21)10-24-26)14-9-17(28-19(14)22)20(27)25-16-11-23-8-7-13(16)12-5-3-2-4-6-12;5-1(3(7)8)2(6)4(9)10/h2-6,9-10,13,16,23H,7-8,11H2,1H3,(H,25,27);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay				J Med Chem 62: 7264-7288 (2019) Article DOI: 10.1021/acs.jmedchem.9b00891 BindingDB Entry DOI: 10.7270/Q2XW4P7W
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