BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Receptor tyrosine-protein kinase erbB-2' and Ligand = 'BDBM376908'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM376908
PNG
(US10329300, Example 2 | US9920060, 2)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H29ClN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-9-14(2)15(10-17(18)26)11-20(36)32(3)4/h5,9-10,13,16H,1,6-8,11-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile...

US Patent US10329300 (2019)


BindingDB Entry DOI: 10.7270/Q2MG7RWF
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))		BDBM376908
PNG
(US10329300, Example 2 | US9920060, 2)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H29ClN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-9-14(2)15(10-17(18)26)11-20(36)32(3)4/h5,9-10,13,16H,1,6-8,11-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 8.30n/an/an/an/an/an/a



Universite Paris 7-Denis Diderot



Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...

Bioorg Med Chem 16: 1242-53 (2008)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair