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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM50564363'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50564363
PNG
(CHEMBL4791998)
Show SMILES Cl.Fc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\OCCN3CCNCC3)c2c1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.320n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human FLT3 D835Y mutant in presence of ATP


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112205
BindingDB Entry DOI: 10.7270/Q2VM4H1R
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50564363
PNG
(CHEMBL4791998)
Show SMILES Cl.Fc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\OCCN3CCNCC3)c2c1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.870n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant His-tagged human FLT3 expressed in baculovirus expression system using peptide substrate incubated for 30 mins in presence ...


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112205
BindingDB Entry DOI: 10.7270/Q2VM4H1R
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))
BDBM50564363
PNG
(CHEMBL4791998)
Show SMILES Cl.Fc1ccc2NC(=O)\C(=C3/Nc4ccccc4/C/3=N\OCCN3CCNCC3)c2c1
PDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a<0.25n/an/an/an/an/a


TBA

Assay Description
Binding affinity to human FLT3 ITD mutant in presence of ATP by Lanthascreen Eu kinase binding assay


Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112205
BindingDB Entry DOI: 10.7270/Q2VM4H1R
More data for this
Ligand-Target Pair